Padecimientos Oncológicos usando Terapia Hiperbarica

Tissue Injury and Chemotherapy – Lesiones a Tejido y la Quimioterapia 
203. Xin PJ, Miao GC, Zong WC, Rong WS, Min LJ, Yingying C, An ZS, Song LT. The influence of hyperbaric
oxygenation on chemotherapy effect in patients with malignant lymphoma. In: Wen-ren Li, pres. Proceedings of
the Eleventh International Congress on Hyperbaric Medicine (Fuzhou, China). Flagstaff, Arizona: Best Publishing
Co.;1993. Pp:44-47.
204. Heys SD, Smith IC, Ross JA, Gilbert FJ, Brooks J, Semple S, Miller ID, Hutcheon A, Sarker T, Eremin O. A pilot
study with long term follow up of hyperbaric oxygen pretreatment in patients with locally advanced breast cancer
undergoing neo-adjuvant chemotherapy. Undersea and Hyperbaric Medicine. 2006;33(1):33-43

Enhancement of Radiotherapy – Potencializador de la Radioterapia
79. Cade IS, McEwen JB. Megavoltage radiotherapy in hyperbaric oxygen: A controlled trial. Cancer. 1967;20:817-821.
80. Brenk Van den HAS. Hyperbaric oxygen in radiation therapy: Investigations of dose-effect relationships in tumour
response and tissue damage. Am J Roentgenology. 1968;102:8-26.
81. Van Den Brenk HA. Hyperbaric oxygen in radiation therapy. An investigation of dose-effect relationships in tumour
response and tissue damage. American Journal of Roetgenology. 1968;102:8-26.
82. Faust DS, Brady LW, Kazem B, Germon PA. Hybaroxia and radiation therapy in carcinoma of the cervix (Stage III
and IV): A clinical trial. In: Wada J, Takashi I, eds. Proceedings of the Fourth International Congress on Hyperbaric
Medicine (Sapporo, Japan). Baltimore: Williams & Wilkins; 1970. Pp:410-414.
83. Henk JM. Hyperbaric oxygen in radiotherapy of head and neck carcinoma. Clin Radiol. 1970;21:223-231.
84. Tobin DA, Vermund H. A randomised study of hyperbaric oxygen as an adjunct to regularly fractionated
radiation therapy for clinical treatment of advanced neoplastic disease. Am J Roentgenol Radium Ther Nucl Med.
1971;3:613-621.
85. Plenk HP. Hyperbaric radiation therapy. Preliminary results of a randomized study of cancer of the urinary bladder and
review of the “oxygen experience.” Am J Roentgenol Radium Ther Nucl Med. 1972;114(1):152-157.
86. Shigematsu Y, Fuchihata, Makino T, Inoue T. Radiotherapy with reduced fraction in head and neck cancer, with
special reference to hyperbaric oxygen radiotherapy in maxillary sinus carcinoma (a controlled study). In: Sugahara
T, Scott OCA, eds. Fraction Size in Radiobiology and Radiotherapy. Tokyo: Igako Shoin; 1973. Pp:180-187.
87. Dische S. The hyperbaric oxygen chamber in the radiotherapy of carcinoma of the uterine cervix. Br J Radiol. 1974.
Pp:99-107.
88. Glassburn JR, Damsker JI, Brady LW, Faust DS, Antoniades J, Prasavinichai S, Lewis GC, Torpie RJ, Asbell SO.
Hyperbaric oxygen and radiation treatment of advanced cervical cancer. Proceedings of the Fifth International
Hyperbaric Congress. Simon Fraser University; 1974. Pp:813-819.
89. Chang CH, Conley JJ, Herbert C. Radiotherapy of advanced carcinoma of the oropharyngeal region under
hyperbaric oxygenation. Am J Roentgenol Radium Ther Nucl Med. 1975;117(3):509-516.
90. Fletcher GH, Lindberg RD, Carderao JB, Wharton JT. Hyperbaric oxygen as a radiotherapeutic adjuvant in
advanced cancer of the uterine cervix: Preliminary results of a randomized trial. Cancer. 1977;39(2):617-23.
91. Henk JM, Smith CW. Radiotherapy and hyperbaric oxygen in head and neck cancer. Interim report of second
clinical trial. Lancet. 1977;8029(2):104-105.
92. Henk JM, Kunkler PB, Smith CW. Radiotherapy and hyperbaric oxygen in head and neck cancer: Final report of
first controlled clinical trial. Lancet. 1977;8029(2):101-103.
93. Perrins D, Wiernik G. The medical research council’s working party on radiotherapy and hyperbaric oxygen.
Controlled trials in carcinoma of the bladder. Br J Radiol. 1978;51(611):876-878.
94. Watson ER, Halnan KE. Hyperbaric oxygen and radiotherapy: A medical research council trial in carcinoma of the
cervix. Br J Radiol. 1978;51:879-887.
95. Cade IS, Dische S, Watson ER, Wiernik G, Sutherland I. Hyperbaric oxygen and radiotherapy: a medical research
council trial in carcinoma of the bladder. Br J Radiol. 1978; 51:876-878.
96. Cade IS, McEwen JB, Dische S, Saunders MI, Watson ER, Halnan KE, Wiernik G, Perrins DJD, Sutherland I.
Hyperbaric oxygen and radiotherapy: A medical research council trial in carcinoma of the bladder. Br J Radiol.
1978;51(611):876-878.
97. Cade IS, McEwen JB. Clinical trails of radiotherapy in hyperbaric oxygen at Portsmouth (1964-1976).
1978;29:333-338.
98. Ward AJ, Dixon B. Carcinoma of the cervix: Results of a hyperbaric oxygen trial associated with the use of the
cathetron. Clin Radiology. 1979;30(4):383-387.
99. Berry GH, Dixon B, Ward AJ. The leeds results of radiotherapy in HBO for carcinoma of the head and neck. Clin
Radiol. 1979;30:591-592.
100. Sause WT, Plenk HP. Radiation therapy of head and neck tumours: a randomised study of treatment in air vs.
treatment in hyperbaric oxygen. International Journal of Radiation Oncology, Biology and Physics. 1979;5:1833-
1836.
101. Brady Lw, Plenk HP, Hanley JA, Glassburn JR, Kramer S, Parker RG. Hyperbaric oxygen for carcinoma of the
cervix – stages IIB, IIIB and IVA: Results of a randomized study by the radiation therapy oncology group. Int J
Radiation Oncology Biol Phys 1981;7(8):991-998.
Copyright © 2019 Undersea and Hyperbaric Medical Society, Inc.
102. Henk JM. Late results of a trial of hyperbaric oxygen and radiotherapy in head and neck cancer: A rationale for
hypoxic cell sensitizers? Int J Radiat Oncol Biol Phys. 1986;12(8):1339-1341.
103. Sealy R, Cridland S, Barry L. Irradiation with misonidazole and hyperbaric oxygen: Final report on arandomized
trial in advanced head and neck cancer. Int J Radiat Oncol Biol Phys. 1986;12(8):1343-1346.
104. Dische S, Saunders M, Sealy R, Werner I, Verma N, Foy C, Bentzen S. Carcinoma of the cervix and the use of
hyperbaric oxygen with radiotherapy: a report of a randomised controlled trial. Radiotherapy and Oncology.
1999;53:93-98.
105. Haffty BG, Peters LJ. Radiation therapy with hyperbaric oxygen at 4 atmospheres pressure in the management
of squamous cell carcinoma of the head and neck: results of a randomized clinical trial. The Cancer Journal from
Scientific American, 1999;5:341-347.
106. Bennett MH, Feldmeier J, Smee R, Milross C. Hyperbaric oxygenation for tumour sensitisation to
radiotherapy. Cochrane Database of Systematic Reviews 2018, Issue 4. Art. No.: CD005007. DOI:
10.1002/14651858.CD005007.pub4

7. Vamvakas EC. Transfusion associated cancer recurrence and post-operative infection: meta-analysis of randomized controlled clinical trials. Transfusion. 1996;36:175-186

Moen, I. and Stuhr, L.E.B. (2012, December). Hyperbaric Oxygen Therapy and Cancer – A Review. Target Oncol. 7(4), 233-42.
Retrieved from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3510426/

Heyboer M 3rd, Milovanova TN, Wojcik S, et al. CD34+/CD45-dim stem cell mobilization by hyperbaric oxygen – changes with oxygen dosage. Stem Cell Res. 2014;12(3):638-645. doi:10.1016/j.scr.2014.02.005

Poff AM, Ward N, Seyfried TN, Arnold P, D’Agostino DP (2015) Non-Toxic Metabolic Management of Metastatic Cancer in VM Mice: Novel Combination of Ketogenic Diet, Ketone Supplementation, and Hyperbaric Oxygen Therapy. PLoS ONE 10(6): e0127407. https://doi.org/10.1371/journal.pone.0127407

Hyperbaric oxygen as a chemotherapy adjuvant in the treatment of metastatic lung tumors in a rat model,Paul M. Petre, MDa. Frank A. Baciewicz Jr, MDb. Stefan Tigan, PhDd. J.Richard Spears, MDc, DOI:https://doi.org/10.1067/mtc.2003.90

Feldmeier J, Carl U, Hartmann K, Sminia P. Hyperbaric oxygen: does it promote growth or recurrence of malignancy?. Undersea Hyperb Med. 2003;30(1):1-18.

Daruwalla J, Christophi C. Hyperbaric oxygen therapy for malignancy: a review. World J Surg. 2006;30(12):2112-2131. doi:10.1007/s00268-006-0190-6

Haroon AT, Patel M, Al-Mehdi AB. Lung metastatic load limitation with hyperbaric oxygen. Undersea Hyperb Med. 2007;34(2):83-90.

Kawasoe Y, Yokouchi M, Ueno Y, Iwaya H, Yoshida H, Komiya S. Hyperbaric oxygen as a chemotherapy adjuvant in the treatment of osteosarcoma. Oncol Rep. 2009;22(5):1045-1050. doi:10.3892/or_00000534

Selvendiran K, Kuppusamy ML, Ahmed S, et al. Oxygenation inhibits ovarian tumor growth by downregulating STAT3 and cyclin-D1 expressions. Cancer Biol Ther. 2010;10(4):386-390. doi:10.4161/cbt.10.4.12448

Schellart NA, Reits D, van der Kleij AJ, Stalpers LJ. Hyperbaric oxygen treatment improved neurophysiologic performance in brain tumor patients after neurosurgery and radiotherapy: a preliminary report. Cancer. 2011;117(15):3434-3444. doi:10.1002/cncr.25874

Mayo Clinic. (2018, January 12). Hyperbaric Oxygen Therapy.
Retrieved from: http://www.mayoclinic.org/tests-procedures/hyperbaric-oxygen-therapy/basics/definition/prc-20019167

Bennett, M.H., Feldmeier, J., Smee, R., and Milross, C. (2018). Hyperbaric Oxygenation for Tumour Sensitisation to Radiotherapy. Cochrane Database of Systematic Reviews. DOI: 10.1002/14651858.CD005007.pub4.
Retrieved from: https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD005007.pub4/full

Delayed Radiation Injuries (Soft Tissue and Bony Necrosis) and Potential – Lesiones retardadas por radiación (necrosis ósea y tejidos blandos) y su potencial
for Future Research
John J. Feldmeier DO, FACRO, FUHM, Laurie B. Gesell MD, FACEP, FUHM
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